The authority and responsibility for the exercise of the DTI mandate is vested in the Secretary who, like his predecessors, is a Presidential appointee who serves office at the pleasure of the President.
At present, the DTI Secretary is Peter B. Favila. 
As DTI Department head, the Secretary has the authority and responsibility for the discharge of DTI's powers and functions. Specifically, his functions are to:
- Advise the President of the Philippines on matters related to trade and investments, and industry, and on the promulgation of Department orders, rules and regulations, and other issuances related to trade, industry, and investments;
- Establish policies and standards for the effective, efficient, and economical operations of the Department in accordance with government programs;
- Supervise and control over all offices, functions, and activities of the Department;
- Delegate authority for the performance of any administrative or substantive function to any Undersecretary or other officials of rank at the Department; and
- Ensure the clear delineation of the functions of personnel and constituent units of the Department, including agencies attached to it, to prevent duplication or overlapping.
Currently, under the Secretary are five Undersecretaries and one Assistant Secretary. The Undersecretaries assist the Secretary in performing his duties by supervising one of the four major functional groups of the Department, namely: Industry and Investments, International Trade, Consumer Welfare and Trade Regulation, and Regional Operations. Specifically, an Undersecretary's functions are to:
- Advise the Secretary in the promulgation of Department orders, administrative orders, and other issuances;
- Supervise over the offices, service, operating units and individuals under his/her authority and responsibility;
- Formulate office rules and regulations, consistent with those of the Department policies, that will effectively implement the activities of operating units under his/her authority and responsibility; and
- Coordinate the functions and activities of the units under his/her authority with those of the other Undersecretaries.
The Assistant Secretary, on the other hand, assist the Secretary and Undersecretaries in the formulation and implementation of laws, policies, plans, programs, and projects on trade and industry, and oversee the day-to-day administration of the Department's constituent units.
DTI Executive Committee
Peter B. Favila
Secretary
Thomas G. Aquino
Senior Undersecretary - International Trade Group (ITG)
Elmer C. Hernandez
Undersecretary - Industry and Investments Group (IIG)
Zenaida Cuison-Maglaya
Undersecretary - Consumer Welfare and Trade Regulation Group (CWTRG)
Zorayda Amelia C. Alonzo
Undersecretary - Small and Medium Enterprises Development Group (SMEDG)
Carissa P. Cruz-Evangelista
Undersecretary - Regional Operations Group (ROG)
Adrian S. Cristobal, Jr.
Director General - Intellectual Property Office (IPO)
Arthur N. Aguilar
General Manager - National Development Company (NDC)
Felicitas R. Agoncillo-Reyes
Assistant Secretary - International Trade Group (ITG)
Ma. Theresa L. Pelayo
Assistant Secretary - Regional Operations Group (ROG)
Ma. Lourdes T. Baua
Assistant Secretary - Management Support Services Group (MSSG)
Ma. Lourdes A. Yaptinchay
OIC - Policy, Planning, and Communications Group (PPCG)
